Has it really been 25 years, a whole quarter of a century? Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Or just depression about the vaccine mandates? Jan 17. Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. JAMA systematic review and meta analysis It doesnt get any better than this. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. In fact, he was unwittingly the source for one of Kirschs figures. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". Once the Phase 2 result came out, it should have been embraced by doctors. I mean, he really, truly has a heart of gold, Char told me. He has been a medical philanthropist for more than 20 years. It will be months before enrollments are complete. So there were too few events in the placebo group and they werent recruiting fast enough. Online Status. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. 4000fluvoxamine750 Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. There is no evidence fluvoxamine is harmful and led to a worse outcome. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Theres nothing there.). While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. . Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. Steve Kirsch is a Silicon Valley philanthropist. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. 1:49 Its all about NIH saying it is OK. . Summary of key evidence. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. @stkirsch. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. If you cant lay off the java, then try fluoxetine (Prozac). Design thinking was supposed to fix the world. But even she was drained by Kirschs constant attempts to override the data. He has made millions from these projects, even if they have not turned him into a household name. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. 1991-1992 to 7.1% in 2001-2002. Medicine isnt about saving lives anymore. Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals Fluvoxamine was reportedly added to just 2 practice guidelines (. Completely avoid caffeine, alcohol, tylenol, and benadryl. Doctors who are most familiar with the drug would prescribe it to their patients. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Several other trials around the world are in the final stages, too. Timing is everything with respect to outcomes. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. The FDA approved Molnupiravir which was less effective. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. That trial has now been completed, and the researchers are analyzing their data. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. Medium revoked my account for life. (Clayton Fox, Marty Makary, and Jeffrey Klausner). Theyre finding alternative leaders to follow, Morris said. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. The medical community did nothing (with a few exceptions like Dr. Seftel). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. It is very important to educate doctors because most people rely on their doctors for advice. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. So it was both obvious and convincing the difference between the groups to the workers and the track management. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. We should not wait for the Phase 3 RCT. Online. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. He may not be a good scientist, but hes smart, says WVUs Feinberg. MD, MPH; Steven C. Marcus, PhD. If you start later, doctors use higher dosages and compliance becomes a bigger problem. We are ignoring the advice of the KOL group and doing nothing. Then he hosted a superspreader event. Steve Kirsch is baffled. May 16, 2022. This advice is now outdated. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. In a recent post, discussing claims Kirsch made during a three-minute comment at an FDA public forum, Morris wrote: In spite of many pages of writing and claims of over a dozen independent analyses verifying their results, their evidence falls far short of substantiating these dramatic conclusions, including a claim that vaccines have caused >250K excess deaths in the USA.. The medical community doesnt care about saving lives. Both drugs have compelling data that is hard to explain if the drug doesn't work. . Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. The NIH never did a risk benefit analysis of this drug. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. Steve angrily decried this development as more evidence of FDA corruption. Thanks for working tirelessly to help others. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Refresh. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. This document is a collection of evidence that highlights the glaring errors in our pandemic response. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. See the repository above. [NIH] doesnt want any of these treatments. That is when the phase 2 results were published. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. . It cant be more clear than this. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. It works best when it is given early, as soon as symptoms start. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? It doesnt get much better than that. We look for advances that will have a big impact on our lives and break down why they matter. Its whether Merck can make a killing that matters. Medicine isnt about saving lives anymore. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. 90,000 people don't have to die in the next 3 weeks. I bumped up the reward to $1M. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. . I was just getting tired, he said, before asking to speak off the record. Physicians who use the drug for COVID now swear by it. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Always be self aware when using fluvoxamine. Most recent articles first. (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. . CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . Dosage there is 30mg once a day. When was the last time you saw a phase 3 fail where there was a 100% effect size in both an RCT and RWE study along with 4 independent observational trials all showing a positive effect, and there is clear mechanism of action where there is less than a 1% chance that it is not working (the SSRI's ordered their impact based on their Sigma activation which is 1 in 120 options), and where in every single case we are aware of the patient taking the drug reversed to normal in an average of 3 days? He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Food/drugs to avoid while on fluvoxamine. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. I see it all the time on social media, Morris told me. CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. In severe cases, it takes longer. Who knows, Morris replied. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. You can help by bringing this document to your doctor's attention. Quick Summary . Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. Weve known it works since August 24, 2020. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Physicians who use the drug for COVID now swear by it. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. The rest of the board soon followed. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? Online. The web price charge of skirsch.io . Three of the four outpatient trials have been reported out: all were successful. I have never heard of a case it didn't work. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. He started 7 high tech companies, two with billion dollar market caps. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. has tons of info on fluvoxamine with all the links. Repurposed drugs are safer and more effective than the current vaccines. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Fluvoxamine, COVID, pandemic, . Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. Hes very convincing. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. Compulsive fiddling with your mask? The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. Its not about the science. Here are the key things you should know about fluvoxamine for COVID: It works. reach out to us at So much for evidence-based medicine. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19?

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