Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Hi, let us know if you have any questions as you visit our website. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? % w !1AQaq"2B #3Rbr Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. %PDF-1.5 MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Trademarks: Avicel PH-102. 1.3. Find answers in our support articles. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. *r_ *?~4$ &0Y# : 160182. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Quantity: 1 700 kgs. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . 1.3. Synergies to simplify formulation challenges and reduce operational costs. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. <> . Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. EMCOCEL XLM 90. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. A., and Smith, P. A. No. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? MATERIAL SAFETY DATA SHEET. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Delivering efficient and robust formulations. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Millipore. }o]X4]. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Thus, Avicel contributes no or very few calories to the food system. Biologicals by FMC. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. This Microcrystalline Cellulose . SUBSTANCE IDENTIFICATION 1.1. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. 0.25 - 0.37. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Product and Company Identification . };khd5x=fr In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. ( endobj Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. cas:9000-11-7 msds Carboxymethyl cellulose. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. There have always been two different points of view for the liquidity of MCC. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" If breathing is difficult or if . Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Performing this action will revert the following features to their default settings: Hooray! Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. 4 0 obj 1 0 obj IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. >> <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> Microcrystalline Cellulose / Avicel PH-102. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. q86@on$^X_HuH;3` FMC, JRS and Mingtai were estimated to hold for . 6 <> Combines good flow and high compactibility. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. JFIF ` ` ZExif MM * J Q Q Q C bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O <> 102331. PharmaCentral 2021 . Test Data Available. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. FMC Corporation. It is also inert and biocompatible. It is also used in plaque assays for counting. undefined. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. stream Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Product Name Cellulose microcrystalline. 2021 Annual Report. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. endobj Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Have an order or account question? MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. /Contents 4 0 R The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. SDS - Safety Data Sheet. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. The cellulose molecule is formed through repeated condensation of cellobiose units. 2 0 obj TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Protect them from sunshine or rain. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. The typical mean particle size is 20200 m. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Microcrystalline Cellulose E460 MSDS 1. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. cas:9032-51-3 msds CELLULOSE PAB. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Magazine: Material safety data sheet - FMC Corporation. q9;v80q>jZ Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. << J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Safety Data Sheet for Cellulose microcrystalline 102331. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Instead, they obtained a stable colloidal suspension. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. gac74 [#B6`Wnw7 The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Catalog Number 102331. Material safety data sheet - FMC Corporation. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . MSDS Ref. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. . These grades have particle sizes ranging from <30 to approximately 200. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream The short-term limit for total inhalable dust is 20 mg/m3. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . G2W4de=u183KGH{ vQ#4:1\wc \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! The aqueous solution to barrier membrane coating. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Page 1 of 8. Watch Now. 0.25 - 0.37. There may be more fiber in your food than you realized. Heavy metals, % NMT 0.001 Microcrystalline Cellulose Side Effects. CoA. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. (1962). ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Microcrystalline cellulose is a commonly used excipient in the . CAS #: 9004-34-6 1.6. The most. We can send by Fedex, by ship or by plane according to international rules. Avicel Microcrystalline Cellulose Physical Properties. AVICEL RC 581. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning.

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